个人简介

吕优优，男，中共党员，博士。2021年12月引入澳门威尼克斯网站为专任教师，研究方向为功能性乳品与益生乳酸菌工程。目前作为负责人主持“国家自然科学基金”“湖北省自然科学基金”“中央高校自主科技创新基金”等科研项目，作为骨干参与科技部重大专项2项。目前已在《Theranostics》《Journal of Agricultural and Food Chemistry》（封面）《Food Chemistry》《Molecular Nutrition & Food Research》《Food & Function》等权威期刊发表研究论文28篇，包括25篇SCI，一作9篇；荣获“山东省高等学校科学技术一等奖”1次；申请专利3项，已公布3项（含授权1项）；参编专著3部（含出版1部）；担任《Food& Function》(TOP期刊)、《Journal of the Science of Food and Agriculture》(TOP期刊)、《Journal of Clinical Microbiology and Biochemical Technology》等SCI及同水平国际学术期刊审稿人。

教育经历

2021年6月毕业于中国海洋大学, 获食品科学博士学位

工作经历

2021.12-至今, 华中农业大学, 澳门威尼克斯网站, 讲师

研究领域

1. 致力于有益微生物资源发掘与利用
2. 致力于有益乳酸菌相关代谢调控机制研究
3. 致力于乳品相关功能活性成分机制研究

科研项目

1. 国家自然科学基金，2023-01至2025-12，30万元，主持。
2. 湖北省自然科学基金，2022-06至2024-06，8万元，主持。
3. 中央高校自主科技创新基金, 2022-01至2024-12, 20万元, 主持。
4. 中华人民共和国科技部，“乳酸菌或蛋白酶水解生产特定功能乳制品产品研究与应用示范”，2018YFC1604302，2018-12至2021-12，2576万元，结题，骨干。
5. 中华人民共和国科技部，“恶性肿瘤姑息治疗和护理关键技术研究”，ZDZX2017ZL-03-02，2017-07至2020-12，50万元，结题，骨干。
6. 国家自然科学基金, “乳脂球膜组成对乳脂结构的影响及机理研究”, 31801500, 2019-01至2021-12, 26万元, 结题, 参与。

成果奖励

【发表论文】
1. Yeting Wu#, Youyou Lu#, Yuhao Huang, Junyu Wang, Siyue Li, Mengyao Xu, Hong Lin, and Zhenxing Li*. Comparative analysis of glycosylation affecting sensitization by regulating the cross-Reactivity of parvalbumins in turbot (Scophthalmus maximus), conger eel (Conger myriaster) and sea bass (Micropterus salmoides). Journal of Agricultural and Food Chemistry, 2022, 70(34):10611-10619（封面）
2. Youyou Lu, Xi Liang, Yeting Wu, Ruiqi Wang, Tongjie Liu, Huaxi Yi, Zhuang Yu, Zhe Zhang, Pimin Gong* & Lanwei Zhang*. Bifidobacterium animalis sup F1-7 acts as an effective activator to regulate immune response via Casepase-3 and Bak of FAS/CD95 pathway. Probiotics and Antimicrobial Proteins, 2022, Doi: 10.1007/s12602-022-09975-9
3. Youyou Lu, Zhuang Yu, Zhe Zhang, Xi Liang, Pimin Gong, Huaxi Yi, Liuqing Yang, Tongjie Liu, Hanping Shi*, Lanwei Zhang*. Bifidobacterium animalis F1-7 in combination with konjac glucomannan improves constipation in mice via humoral transport. Food & Function, 2021, 12(2):791-801
4. Youyou Lu, Zhe Zhang, Lingjun Tong, Xiaohong Zhou, Xi Liang, Huaxi Yi1, Pimin Gong, Tongjie Liu, Lanwei Zhang*, Liuqing Yang, Hanping Shi*. Mechanisms underlying the promotion of 5-hydroxytryptamine secretion in enterochromaffin cells of constipation mice by Bifidobacterium and Lactobacillus. Neurogastroenterology and Motility, 2021, 33: e14082
5. Youyou Lu#, Junxue Zhang#, Xiaohong Zhou, Meiyu Guan, Zhe Zhang, Xi Liang, Lingjun Tong, Huaxi Yi, Pimin Gong, Lu Bai, Hui Zhou, Tongjie Liu*, Lanwei Zhang*. The edible Lactobacillus paracasei X11 with Konjac glucomannan promotes intestinal motility in zebrafish. Neurogastroenterology and Motility, 2021, 33: e14196
6. Youyou Lu#, Junxue Zhang#, Zhe Zhang, Xi Liang, Tongjie Liu, Huaxi Yi, Pimin Gong, Lingli Wang, Wenjun Yang, Xinyi Zhang, Lanwei Zhang*, Liuqing Yang, Hanping Shi*. Konjac glucomannan with probiotics acts as a combination laxative to relieve constipation in mice by increasing short-chain fatty acid metabolism and 5-hydroxytryptamine hormone release. Nutrition, 2021, 84:111112
7. Youyou Lu, Zhe Zhang, Xi Liang, Yujie Chen, Junxue Zhang, Huaxi Yi, Tongjie Liu, Liuqing Yang, Hanping Shi*, Lanwei Zhang*. Study of gastrointestinal tract viability and motility via modulation of serotonin in a zebrafish model by probiotics. Food & Function, 2019, 10(11):7416-7425
8. Youyou Lu, Junxue Zhang, Huaxi Yi, Zhe Zhang, Lanwei Zhang*. Screening of intestinal peristalsis-promoting probiotics based on a zebrafish model. Food & Function, 2019, 10(4):2075-2082
9. Youyou Lu, Nana Wang, Jiao He, Yanfang Li, Xiaoning Gao, Lili Huang*, Xia Yan*. Expression and characterization of a novel chitinase with antifungal activity from a rare actinomycete, Saccharothrix yanglingensis Hhs.015. Protein Expression and Purification, 2018,143:45-51
10. Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Guanzhi Chen, Yan Chen, Zhenxing Li*. Glycosylation reduces the allergenicity of turbot (Scophthalmus maximus) parvalbumin by regulating digestibility, cellular mediators release and Th1/Th2 immunobalance. Food Chemistry, 2022,382:132574
11. Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Mengyao Xu, Ishfaq Ahmed, Guanzhi Chen, Yan Chen, Zhenxing Li*. Fish allergens of turbot (Scophthalmus maximus) parvalbumin triggers food allergy via inducing maturation of bone marrow derived dendritic cell and driving Th2 immune response. Food & Function, 2022,13:4194-4204
12. Yeting Wu, Youyou Lu, Yuhao Huang, Hong Lin, Xuewen Dang, Yujie Jing, Zhaocheng Meng, Xiangchen Wang*, Zhenxing Li*. Insight analysis of the cross sensitisation of multiple fish parvalbumins via the Th1/Th2 immunological balance and cytokine release from the perspective of safe consumption of fish, Food Quality and Safety, 2022, Doi:10.1093/fqsafe/fyac056
13. Xi Liang, Youyou Lv, Zhe Zhang, Huaxi Yi, Tongjie Liu, Rui Li, Zhuang Yu, Lanwei Zhang*. Study on intestinal survival and cholesterol metabolism of probiotics. LWT-Food Science and Technology, 2020, 124: 109132
14. Xi Liang, Zhe Zhang, Youyou Lv, Haiyan Lu, Tongjie Liu, Huaxi Yi, Maozhen Zhao, Lanwei Zhang *，Pimin Gong*. Krill oil combined with Bifidobacterium animalis subsp. lactis F1-7 alleviates the atherosclerosis of ApoE-/- mice. Foods, 2021, 10, 2374
15. Zhe Zhang, Xi Liang, Youyou Lv, Huaxi Yi, Yujie Chen, Lu Bai, Hui Zhou, Tongjie Liu, Rui Li, Lanwei Zhang*. Evaluation of probiotics for improving and regulation metabolism relevant to type 2 diabetes in vitro. Journal of Functional Foods, 2020, 64:103664
16. Xi Liang, Zhe Zhang, Youyou Lv, Linjun Tong, Tongjie Liu, Huaxi Yi, Xiaohong Zhou, Zhuang Yu, Xiaoying Tian, Qingyu Cui, Jiebing Yang, Pimin Gong, Lanwei Zhang*. Reduction of intestinal trimethylamine by probiotics ameliorated lipid metabolic disorders associated with atherosclerosis. Nutrition, 2020, 79:110941
17. Yeting Wu, Hong Lin, Youyou Lu, Yuhao Huang, Binaka Prabashini Dasanayaka, Ishfaq Ahmed, Guanzhi Chen, Yan Chen, Zhenxing Li*. Allergenicity determination of Turbot parvalbumin for safety of fish allergy via dendritic cells, RBL-2H3 cell and mouse model. European Food Research and Technology, 2021,1-16
18. Lingjun Tong, Haining Hao, Zhe Zhang, Youyou Lv, Xi Liang, Qiqi Liu, Tongjie Liu, Pimin Gong, Lanwei Zhang, Fangfang Cao, Giorgia Pastorin, Chuen Neng Lee, Xiaoyuan Chen, Jiong-Wei Wang*, Huaxi Yi*. Milk-derived extracellular vesicles alleviate ulcerative colitis byregulating the gut immunity and reshaping the gut microbiota. Theranostics, 2021, 11(17): 8570-8586
19. Zhe Zhang, Xi Liang, Lingjun Tong, Youyou Lv, Huaxi Yi, Pimin Gong, XiaoyingTian, Qingyu Cui, Tongjie Liua*, Lanwei Zhang*. Effect of Inonotus obliquus (Fr.) Pilat extract on the regulation of glycolipid metabolism via PI3K/Akt and AMPK/ACC pathways in mice. Journal of Ethnopharmacology, 2021, 273:113963
20. Xi Liang, Zhe Zhang, Xiaohong Zhou, Youyou Lu, Rui Li, Zhuang Yu, Lingjun Tong, Pimin Gong, Huaxi Yi, Tongjie Liu*, Lanwei Zhang*. Probiotics improved hyperlipidemia in mice induced by a high cholesterol diet via downregulating FXR. Food & Function, 2020, 11(11):9903-9911
21. Zhe Zhang, Hui Zhou, Lu Bai, Youyou Lv, Huaxi Yi, Lanwei Zhang*, Rui Li*. Protective effects of probiotics on acute alcohol-induced liver injury in mice through alcohol metabolizing enzymes activation and hepatic TNF-α response reduction. Journal of Functional Foods, 2019, 59:234-241
22. Lingjun Tong, Haining Hao, Xinyi Zhang, Zhe Zhang, Youyou Lv, Lanwei Zhang, Huaxi Yi*. Oral administration of bovine milk-derived extracellular vesicles alters the gut microbiota and enhances intestinal immunity in mice. Molecular Nutrition & Food Research, 2020, 64(8):1901251（封面）
23. Zhe Zhang#, Hui Zhou#, Meiyu Guan, Xiaohong Zhou, Xi Liang, Youyou Lv, Lu Bai, Junxue Zhang, Pimin Gong, Tongjie Liu, Huaxi Yi, Jingfeng Wang, Lanwei Zhang*. Lactobacillus casei YRL577 combined with plant extracts reduce markers of non-alcoholic fatty liver disease in mice. British Journal of Nutrition, 2020, 28:1-11
24. Zhe Zhang#, Hui Zhou#, Xiaohong Zhou, Jize Sun, Xi Liang, Youyou Lv, Lu Bai, Junxue Zhang, Pimin Gong, Tongjie Liu, Huaxi Yi, Jingfeng Wang, Lanwei Zhang*. Lactobacillus casei YRL577 ameliorates markers of non-alcoholic fatty liver and alters expression of genes within the intestinal bile acid pathway. British Journal of Nutrition, 2021, 125(5):521-529
25. Zhe Zhang#, Lu Bai#, Meiyu Guan, Xiaohong Zhou, Xi Liang, Youyou Lv, Huaxi Yi, Hui Zhou, Tongjie Liu*, Pimin Gong, Jize Sun*, Lanwei Zhang*. Potential probiotics Lactobacillus casei K11 combined with plant extracts reduce markers of type 2 diabetes mellitus in mice. Journal of Applied Microbiology, 2021, 131, 1970-1982
【申报专利】
1. 张兰威，吕优优，公丕民，刘同杰，易华西，张喆，梁曦。一株促肠蠕动动物双歧杆菌亚种F1-7及应用。（授权号CN 113564067 B）
2. 公丕民，吕优优，张兰威，刘同杰，易华西，张喆，梁曦。一株副干酪乳杆菌X11及其组合物便秘复合制剂及乳制品。（公布号CN 112694989 A）
3. 张兰威，吕优优，公丕民，刘同杰，易华西，张喆，梁曦。一株动物双歧杆菌F1-7、组合物、粪便干结复合制剂及果乳制品。（公布号CN 113186113 A）
【已出版专著】
《肿瘤微生态学》/石汉平等主编.北京:科学出版社，2021.6 ISBN 9787030691347
【荣誉奖励】
1. “第十六届益生菌与健康国际研讨会优秀论文奖”，2021；
2. “中国海洋大学食品科学与工程学院模范共产党员”，2021
3. 吕优优（8/10），益生乳酸菌定向筛选及其高活性产品开发的关键技术，“山东省高等学校科学技术奖一等奖”，2020；
4. “中国海洋大学食品科学与工程学院硕博研究生学术论坛口头汇报一等奖”，2019；
5. “中国海洋大学优秀博士研究生”，2018；
6. “西北农林科技大学生命科学学院优秀毕业生”，2017；
7. “河南省省级优秀毕业生” “校级优秀毕业论文”，2015；
8. “国家励志奖学金”，2012
【学术兼职】
受邀作为《Food& Function》(TOP期刊)、《Journal of the Science of Food and Agriculture》(TOP期刊)、《Journal of Clinical Microbiology and Biochemical Technology》等SCI及同水平国际学术期刊审稿人。

其它

1. 主持“西北农林科技大学旱区作物逆境生物学国家重点实验室第三届研究生学术论坛”
2. 主持“中国海洋大学食品科学与工程学院2019年硕博研究生学术论坛博士专场”
3. 2018-2020年担任“中国海洋大学食品科学与工程学院功能性乳品与益生菌工程实验室主任助理”，全面负责协助导师实验室管理事宜